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The efficient movement of basic science discoveries into clinical applications often described as "bench to bedside" work is the goal of translational research.
Animal models are extremely important in understanding this interface as well as in bridging the gap between basic science discoveries and clinical medicine.
By building on basic science discoveries in the academic setting, applied science can perform proof-of-concept work with simple, benchtop experiments.
Agre, currently the director of the Johns Hopkins Malaria Research Institute in Baltimore, Maryland, is now using his basic science discoveries about aquaporins to understand the role the proteins play in the parasite that causes malaria.
Biologically relevant animal model studies remain necessary to enhance understanding regarding the mechanisms by which fluid resuscitation affects the microcirculation and to facilitate the transfer of basic science discoveries to clinical applications.
He described how Big Pharma relies on the basic science discoveries made early on in the lab to develop drugs for patients who need them so desperately.
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Further elucidation and modeling of medical translational research is highlighted by the National Cancer Institute (NCI) in their translational continuum schematic, which outlines five phases of translational research: basic science discovery, early translation, late translation, dissemination, and adoption [8].
Clinical research is the cornerstone of evidence-based medical practice and the key translational step from basic science discovery to benefits for individual patients.
The explosion in biomedical research and the use of computers to access and disseminate ideas has increased our knowledge but has also strikingly shortened the time for new concepts to move from initial basic science discovery to clinical application.
A highly sensitive and specific approach towards translocation detection would allow for a more complete molecular profile that would both support the basic science discovery process, and would be of great use to the clinical care of patients.
This could potentially expedite the journey from basic science discovery to clinical utility, a translation process which to date has had limited success in the applications of 'omics technologies in maternal-fetal newborn health.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com