While basic science and animal studies can provide important clues to the underlying pathophysiology of many human ailments, some nuances of human disease are not translatable from these models.
Exclusion criteria included (1) basic science, (2) animal models, cadaver studies or studies of an asymptomatic population, (3) biomechanical studies not reporting clinical outcomes, (4) studies reporting only imaging (X-ray, ultrasound, computed tomography or magnetic resonance imaging with no clinical assessment), and (5) systematic reviews.
Although basic science and animal research have clearly established the role of reactive oxygen species in the progression of vascular disease, the failure of clinical trials with antioxidant compounds has underscored the need for better antioxidant therapies and a more thorough understanding of the role of reactive oxygen species in cardiovascular physiology and pathology.
They highlighted basic science and animal studies which found that engrafted MSCs were less able to regulate growth patterns and how this could potentially lead to breast cancer recurrence.
The current medical literature has provided us with a growing body of knowledge in studies of basic science, epidemiology, animal, and even human clinical trials that implicate inflammation in the pathogenesis of MS, IR, PD, T2DM and atheroscleropathy with their morbid, deadly intersection.
24 First, basic science and animal studies support the concept of repetitive alveolar epithelial cell stress due to an array of potential inciting agents in the pathogenesis of IPF. 3, 24 Second, epidemiologic studies have observed geographic variation within countries in the occurrence of IPF, particularly in highly industrialized regions.
The use of P-selectin for flow-mediated enrichment of haematopoietic progenitors holds the potential not only to improve on current cell-isolation techniques in basic science and laboratory animal research (as we have shown), but holds a potential for translation to human benefit in the clinic.
Volume I is mainly focused on the basic science of and related animal experiments on CMV; volume II is aimed at the clinical reader, again with chapters on relevant animal model studies.
"The path to a new drug starts with the basic science — you study an animal model of the disease, and that's where you discover a drug target," Dr. Sandberg said.
