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Limitations of animal infection models have engendered longstanding obstacles in basic science and translational research.
CRISPR/Cas9 genome engineering offers exciting applications in both basic science and translational research.
This paper reviews the foundational basic science and translational research which lead to a pivotal multicenter randomized clinical trial in postmenopausal women with both periodontitis and systemic (skeletal) osteopenia.
In this review, we provide an overview of the CRISPR-Cas systems for genome engineering, and in particular, stress key toolsets and methodologies that we believe will have particularly broad impact on both basic science and translational research.
The first section by Drs. Rosen and Myerburg is an independent review that analyzes the basic science and translational strategies supporting the rapid advance of stem cell technology to the clinic, the philosophies behind them, trial designs, and means for going forward that may impact favorably on progress.
In addition, the bridge between basic science and translational research will be discussed.
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And Eric Boerwinkle, a human geneticist at the University of Texas Health Science Center at Houston is confident Green will set the good course for the $500 million institute: "He will be able to strike the right balance between basic science and applied translational research".
Ongoing and future basic science and clinical translational collaborations will continue to dissect the precise pathways driving how these mutations remodel the heart, and identify rational targets for therapies designed to interrupt the emergence of pathology.
The space between basic science and drug approval the translational piece has come to be known as the "valley of death," because many promising findings never make it to market.
The NIH is the most important source of funding for research related to human diseases and until 3-4 years ago, it supported about 25% of all medical studies, both in basic sciences and as translational applications.
Bruns says the program, which counts 193 students in the 13 programs, has three goals: to foster collaboration between basic science and clinical faculty; to launch translational research projects for students to work on; and, of course, to build a new generation of translational researchers.
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basic science and commercial
basic science and fundamental
basic science and technological
basic neuroscience and translational
basic science and epidemiological
basic science and common
basic science and industrial
basic science and medical
basic science and basic
basic science and biomedical
basic science and social
basic mechanism and translational
basic science and deliverable
basic science and clinical
basic science and preclinical
basic science and training
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