Sentence examples for basic residues within the from inspiring English sources

We show that PCNA recognizes the DNA structure through a set of basic residues within the ring channel organized to match the pitch of B-DNA, establishing short-lived polar interactions with consecutive DNA phosphates.

Using crystallography, NMR and molecular dynamics simulations, here we show that the human clamp PCNA recognizes DNA through a double patch of basic residues within the ring channel, arranged in a right-hand spiral that matches the pitch of B-DNA.

It has been previously proposed that the basic residues within the ZFs of Krüppel-like factor KLF1 may represent a common NLS motif for all KLF members [21].

Within importin-α, the major NLS binding pocket contains a series of negatively charged residues that form salt bridges with the basic residues within the NLS sequences [51].

Previously, members of PC-family namely: Furin, PC1/3, PC2, PC4, PACE4, PC5/6 and PC7 have been reported to be involved in the processing of various substrates at basic residues within the general motif (K/R - X n- K/R)↓ where n = 0, 2, 4 or 6 and X is any amino acid except Cys, [9]-[12].

Furthermore, the loop and basic residues within the loop are required for talin-mediated β1-integrin activation.

Most importantly, an improved scoring system has been introduced that applies ion type weighting depending on the charge state and the localization of the basic residue within the precursor peptide.

An acidic residue binding to the 2′ and 3′ hydroxyls of the adenine ribose and located downstream of the Gly-rich motif confers NAD(H) specificity, whereas NADP(H) binding is dictated by the presence of a basic residue within the Gly-rich segment.

In this conformation, basic residues within helix-B of the Hin catalytic domain (Lys47, Arg48, and Lys51, displayed as sticks) are close to the enhancer DNA, and the flat interface enabling subunit rotation has formed.

Given these previous findings, we therefore mutated the basic residues within ZF1 and ZF2 to more precisely define and map the amino acids involved in KLF6 nuclear localization.

The observed linear distribution of acidic and basic residues within coil 1b and coil 2 could allow the formation of several stabilizing ionic interactions.