Sentence examples for basic residues into the from inspiring English sources

In line with this suggestion was the observation that introduction of two basic residues into the transmembrane segment resulted in mislocalisation to the cytosol.

However, introduction of basic residues into the portal region of the 5-HT3AB heteresultedsulted in significant increases in EC50 values (Table  2009).

Introduction of the two "missing" site II basic residues into GII or GII-L destabilised the protein and led to decreased chromatosome protection relative to the protein without the basic residues.

However, p38 kinases have additional acidic residues in their docking regions [ 37] and the introduction of basic residues into target proteins can promote p38 specificity [ 38].

We also introduced charge-reversal mutations to basic residues in the ZFD.

These interactions bring the basic residues in the flanking basic region close to the PWI domain, promoting directly the formation of an enlarged basic-residue-rich region.

To verify this hypothesis, the 12 basic residues in the PWI domain were mutated to alanine.

To test this hypothesis, all the basic residues (Lysine) in the region were substituted for the acidic residues (Aspartate).

We next examined the spatial relationship of the basic residues essential for the NLS.

Interhelical salt bridges and charge-stabilized hydrogen bonds between acidic and basic residues of the two monomers are predicted to form an interaction domain, which does not follow the classical knobs-into-holes zipper model.

c-Raf seems to have a strong preference for basic residues at the −3 position and hydrophobic residues at the +1 position relative the phosphorylated serine/threonine residue.