Secondly, we show directly that basic residues in the gp64 unstructured loop influence entry and that increasing basicity can improve entry.
We also introduced charge-reversal mutations to basic residues in the ZFD.
Basic residues in the insert inhibit the activity of AS likely through an auto-inhibitory mechanism (Hergovich et al., 2006).
These results indicate the importance of several basic residues in the 310 helical region and the N-terminal zinc finger, and rationalize the presence of several evolutionarily conserved residues in NC.
These non-specific interactions are formed through basic residues in the histones making ionic bonds to the acidic sugar-phosphate backbone of the DNA, and are therefore largely independent of the base sequence.
Substitution of basic residues in the PS site led to localization of mutant protein in the cytosol.
The genetic algorithm was constrained using several criteria, such as the number of acidic and basic residues in the peptide.
This demonstrates the importance of both hydrophobic and basic residues in the antifungal activity of a defensin.
The basic residues in the surface must be in the right positions (i.e. in all directions) to induce membrane aggregation.
There are seven basic residues in the binding pocket; so the designed peptide stabilizes itself by electrostatic complementarity and the salt bridge formation.
Interestingly, in-silico analysis of amino-acid sequences of NMDA-R subunits revealed a potential stretch of basic residues in the first intracellular loop of NR2C (unpublished results).
