Sentence examples for basic residue in the from inspiring English sources
Interestingly, further residue mutant experiments showed that a single basic residue in the filter region determined the insensitivity of KCNQ1 channels toward scorpion toxins.
Telezhkin, V., Thomas, A. M., Harmer, S. C., Tinker, A. & Brown, D. A. A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI 4,5 P(2).
All viruses lacking a basic residue in the HA cleavage site belong to sublineages E-F (Figure 4).
This contact likely contributes to Rho/effector specificity, because other E. histolytica Rho family GTPases lack a basic residue in the position corresponding to Arg30.
ETD fragmentation near TMD boundaries (intermediate TMHMM scores) can be attributed to the presence of a basic residue in the neighboring soluble region.
Importantly, there is no basic residue in the vicinity of the substrate binding site (see Figure 5), suggesting that the observed p Ka's are not due to a basic residue that itself acts on the bound amino acids.
Secondly, we show directly that basic residues in the gp64 unstructured loop influence entry and that increasing basicity can improve entry.
(a) Schematic representation of p53 domains (top). 1 or 6 basic residues in the CTD were mutated to glutamine (Q) to generated PI4,5P2-binding defective mutant R379Q or 6Q.
These results indicate the importance of several basic residues in the 310 helical region and the N-terminal zinc finger, and rationalize the presence of several evolutionarily conserved residues in NC.
Thus, a critical PIP2 binding site in Kv7.1 and Kv7.2 channels is located at the VSD-pore domain interface, where PIP2 headgroups are engaged in electrostatic interactions with basic residues in the VSD and the proximal C-terminus (including the S6 gathereby, therebridginging these two domains and providing structural stabilization1.
