This potential for direct, effectively unlimited scalability is expected to significantly accelerate clinical and pharmaceutical applications of pluripotent cells by permitting promising basic-research observations to be translated into a production environment rapidly and efficiently, without the need to reformulate processes using a different set of procedures.
Regenerative Medicine is an emerging field that combines basic research and clinical observations in order to identify the elements required to replace damaged tissues and organs in vivo and to stimulate the body's intrinsic regenerative capacity.
While using AOT to treat osteochondral defects is very common in clinical practice [ 22– 24], accumulating evidence from basic research to clinical observation has given orthopedists reason to pause.
The Manchester example hinted at a novel (if still empire-building) integration of clinical, epidemiological, and laboratory research, drawing on local ethnic communities as a research resource; the program at Middlesex reiterated established colonial divisions between basic research and clinical observation.
The basic research and the clinical observations "all fit together like a nice neat glove," said Dr. Lammer.
All in all, clinical observations and basic research results agree that excessive fat inside the abdomen is a major contributor to cardiovascular disease.
Both clinical observations and basic research have indicated a potential link between inflammation and lipid metabolism.
The development of many accomplishments of modern medicine clearly derives from serendipitous or hypothesis-driven observations of basic research.
Experimental research has always been the cornerstone of pathophysiological and therapeutic advances in critical care medicine, where clinical observations and basic research mutually fed each other in a so-called translational approach.
Additionally, knowledge in translational medicine can also flow in the contrary direction, resulting in the initiation of new basic research based on the clinical observations of a disease development.
Increasing evidence from clinical observations and basic research reveals the great heterogeneity of B cells, indicating that, in addition to B10 cells, there are likely more cytokine-producing subsets of B cells that exert multiple antibody-independent, non-classical functions during pathological processes than previously thought.
