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The evolving knowledge gained from multidisciplinary basic research has begun to identify new concepts for treatments and distinct classes of therapeutic targets; as well as putative disease-modifying compounds that are now being tested in clinical trials.
In the recent years, basic research has begun to define parameters for experimental cell-based treatments that are likely to be translationally relevant.
Basic research has begun to show that Aβ and α-syn may act synergistically to promote the aggregation and accumulation of each other.
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In addition to numerous case series from Asia, a growing body of basic scientific research has begun to elucidate the pathophysiology of this particular infection.
Against this background, basic and applied research has begun to assess the therapeutic potential of combinations of these molecules – either with one another [e.g. amylin with murine leptin (Trevaskis et al., 2008)] or with a centrally acting agent [e.g. amylin or pramlintide with either phentermine or sibutramine (Roth et al., 2008; Arrone et al., 2010)].
The National Institutes of Health, which is an influential leader in determining the direction of research, has begun to introduce new expectations for inclusion of female as well as male animals and sex-typing of cell lines in basic research [ 65].
Recently, research has begun to investigate metacognition in college courses.
Remarkably, recent research has begun to answer these questions.
Government funding of basic research has been astonishingly productive".
The basic approach, however, has begun to emerge.
In addition, nuclear activation analysis and the study of nuclear reactions of astrophysical interest has begun to be developed as basic research.
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