The Human Frontier Sciences Program, which funds "basic research focused on complex mechanisms of living organisms," has made traveling across borders its mission.
Therefore, basic research focused on the mechanisms of development provides an essential foundation for pediatric solid tumor translational research.
Although your description of your proposed research is very brief, to me it sounds like a good fit with HFSP's goal of supporting "basic research focused on complex mechanisms of living organisms"; anyway, you could successfully spin it that way.
Participants were challenged to think broadly and beyond their basic research foci and specific areas of expertise, identifying means to facilitate integration and interaction with clinicians and public health practitioners.
The specificity of the cellular miRNA repertoire and its sensitivity to a large panel of intra/extracellular stimuli and characteristics (including gender and age) have stimulated interest not only in basic research focused on deciphering the contribution of miRNAs to cancer development, but also in more applied research aimed at evaluating miRNAs' potential in cancer personalized medicine.
Our belief is that basic research should focus on means to target tolerogenic APC; to promote, for example through the use of appropriate adjuvants, secretion of IL-10 from both APC and T cells; and to investigate the mechanisms of dose escalation tolerance.
In the treatment of cancer, basic research is focused on targeted therapies – treatments directed at the characteristics of a particular tumour, such as gene mutations or particular proteins.
But such efforts often stumble, Schultz says, because the culture of basic research, which focuses on insights from individual investigators, is often at odds with translational efforts, which require highly integrated teamwork.
Another basic research article focuses on the study of microvessel density and its survival implications among women with uterine leiomyosarcoma.
At present, basic research is focused on the cancer microenvironment of individual tumours to explore tumour heterogeneity (Hanahan and Weinberg, 2011).
