The focus of this office will be to accelerate the application of basic research discoveries to patient treatment and disease prevention, both nationally and internationally.
The central conclusion of the paper is that the field needs to work towards development of more patient-applicable endophenotypes to allow for successful translation of basic research discoveries to successful therapeutic development.
Clinical, translational, and basic research discoveries are creating waves of novel target and treatment development possibilities for individuals with FXS.
Begun in 1982 to help commercialize basic research discoveries, the program receives 2.5% of the budgets of 11 science agencies.
Thus, cross-mappings between the anatomical ontologies will facilitate the integration of mouse and human data, and promote the translation of basic research discoveries into clinical settings.
Links between mouse and human anatomy terms based on the mappings will facilitate closer integration of human and mouse data, promote the use of the mouse as a model for biomedical research, and accelerate translation of basic research discoveries into new clinical therapies.
Many basic research discoveries have been translated into novel diagnostics, antiviral and antimicrobial compounds, and vaccines, often with extraordinary speed.
In the alcohol research field, basic-research discoveries have led to the identification of four of the five medications currently approved for treatment of alcohol use disorder (AUD) in Europe or the United States.
Scientists and clinicians are familiar with Affymetrix Genechip™ arrays being utilized predominantly in the areas of basic research, target discovery, and target validation.
One is the rapid production of recombinant proteins, in the quantities required for basic research, drug discovery and preclinical studies, using stable pools of transfectants.
