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However, when the introns were present in the basic regions, the positions of P0 and P2 were variable.
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Similarly to its flanking basic region, the PWI domain probably binds nucleic acids using its positively charged region.
After the deletion of the flanking basic region, the RBM25 PWI domain was unable to bind to RNA/DNA, meaning that the flanking basic region is essential for RNA/DNA binding.
Shown at the top are the boundaries used in this study to distinguish the DNA-binding basic region, the two a-helices and the variable loop region.
The specificity of the different members of the MAPK family and of the different isoforms of p38 MAPK is provided by a docking motif usually composed of three domains: the basic region, the LXL motif, and the hydrophobic region.
As shown in figure 3C, the basic regions include the central glycine-rich sequence and the C-terminal basic tail.
Arrows denote the basic regions surrounding the B-helices.
The basic regions of the MYB domains had around 103 amino acid residues, with rare deletions or insertions as previously reported [ 32].
In fact, the N-terminal tails are the most basic regions of the core histones, as they contain no acidic residues, and include 38 and 45 mol % basic residues, for H2A and H2B, respectively.
Although heparin has not been implicated in binding to Slit2 D4, the large basic regions and the conspicuous sulphate-binding site suggest a possible interaction.
Individual COGs conserved in both the acidic and basic regions of the trimodal distribution are identified, and orthologs that best represent the variation in levels of the acidic and basic regions are listed.
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