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The basic regions of the MYB domains had around 103 amino acid residues, with rare deletions or insertions as previously reported [ 32].
Other regions of the aptamer make extensive interactions with the large lobe of the kinase domain, remodeling basic regions of the protein so that they can better interact with the polyanionic phosphodiester backbone of the RNA.
Pairwise analysis of pI variation show that a few COGs are conserved within, but most vary between, the acidic and basic regions of the distribution, while molecular mass is more highly conserved.
In fact, the N-terminal tails are the most basic regions of the core histones, as they contain no acidic residues, and include 38 and 45 mol % basic residues, for H2A and H2B, respectively.
Individual COGs conserved in both the acidic and basic regions of the trimodal distribution are identified, and orthologs that best represent the variation in levels of the acidic and basic regions are listed.
Similar(55)
Furthermore, a more stringent analysis of the basic region of the chromatograms indicated that the cationic proteins of the shield, grouped in discrete pI ranges, display a different distribution when compared to the cytosolic pool with an evident selection of the proteins with higher pI values (pI>8.0) (Figure 3D).
Activity can be further enhanced by phosphoinositides binding to a basic region of the WASP molecule.
The DNA-binding activity of target genes is determined in the basic region of the bHLH domain [ 6].
The basic region of the bHLH domain can bind to DNA and is critical for function [ 52].
Similarly to the basic region of the SRm160 PWI domain, the RBM25 PWI domain without the flanking basic region was unable to bind RNA/DNA.
They determined that mutation of the basic region of the transcription factors reduced their phosphorylation by both phospho-ERK2 and phospho-p38 [ 21].
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