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Chukkapalli, V., Oh, S. J. & Ono, A. Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain.
The basic region of the Diaphanous-autoregulatory Domain (DAD) is required for autoregulatory interactions with the Diaphanous-related formin inhibitory domain.
Fouchier, R. A., Meyer, B. E., Simon, J. H., Fischer, U. & Malim, M. H. HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.
Furthermore, a more stringent analysis of the basic region of the chromatograms indicated that the cationic proteins of the shield, grouped in discrete pI ranges, display a different distribution when compared to the cytosolic pool with an evident selection of the proteins with higher pI values (pI>8.0) (Figure 3D).
Activity can be further enhanced by phosphoinositides binding to a basic region of the WASP molecule.
The basic region of the bHLH domain can bind to DNA and is critical for function [ 52].
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The basic regions of the MYB domains had around 103 amino acid residues, with rare deletions or insertions as previously reported [ 32].
Individual COGs conserved in both the acidic and basic regions of the trimodal distribution are identified, and orthologs that best represent the variation in levels of the acidic and basic regions are listed.
In fact, the N-terminal tails are the most basic regions of the core histones, as they contain no acidic residues, and include 38 and 45 mol % basic residues, for H2A and H2B, respectively.
Other regions of the aptamer make extensive interactions with the large lobe of the kinase domain, remodeling basic regions of the protein so that they can better interact with the polyanionic phosphodiester backbone of the RNA.
Pairwise analysis of pI variation show that a few COGs are conserved within, but most vary between, the acidic and basic regions of the distribution, while molecular mass is more highly conserved.
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