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Prendergast, G.C. & Ziff , E.B. Methylation-sensitivesequence-specific DNA binding by the c-Myc basic region.
The acidic N-terminal extension is hypothesized to form an heterodimeric coiled-coil structure with the basic region, essentially zippering the leucine zipper into the basic region.
The basic region is also essential for oxidative stress-inducible transcription of CUP1 by Hsf1.
Sequence-specific interactions are proposed between the basic region and the invariant cis elements that all bHLH-Zip proteins bind.
basic region leucine zipper.
Specificity of DNA binding has been predicted to be imparted by the basic region.
A basic region in the cytosolic domain of Sec61β is critical for microtubule association.
The basic region and leucine repeats are indicated by the bar and arrows, respectively.
In both of the recombinant polypeptides, DNA binding specificity is shown to track with the basic region.
These two assays identify different requirements for the Basic region.
The basic region facilitates DNA interactions and the HLH domain, protein dimerizations [2], [3].
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