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This work also provides important evidence as to why translocation of the mRNA that encodes myelin basic protein is important in the assembly of the myelin sheath since premature synthesis seems to provoke aberrant, ectopic compaction of the myelin membrane.
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Fouchier, R. A., Meyer, B. E., Simon, J. H., Fischer, U. & Malim, M. H. HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.
That same protein is important in keeping cancers alive as they spread through the body.
This observation suggests that the basic nature of IQD proteins is important for their biochemical functions.
"We could tell what part of the protein was important, but we couldn't tell why".
Myelin basic protein was from Sigma.
MBP (myelin basic protein) was from Millipore (catalogue number 13-104).
Because proteins are important.
Highly basic proteins are known to contaminate microtubule preparations owing to charge interactions4, and we noted some highly basic ribosomal proteins as recognizable contaminants.
Their investment in basic research is important.
Modulation of protein binding specificity is important for basic biology and for applied science.
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