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We showed that this neurosphere system is able to reveal exogenously induced disturbances in these basic processes of brain development.
Human neurospheres are likely to imitate basic processes of brain development, and these processes can be modulated by developmental neurotoxicants.
However, their applicability is limited to basic processes of brain development, because they do not resemble complex higher brain structure development such as formation of cortical layers.
We established assays suitable for detecting disturbances in basic processes of brain development by employing human neural progenitor cells (hNPCs), which grow as neurospheres.
Because these end points extend beyond the basic processes of brain development, the basic "neurosphere assay" (Breier et al. 2009) cannot detect such changes.
The system is also limited to basic processes of brain development—no synaptic function, so far no network function, no higher cognitive functions to evaluate".
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These three-dimensional cell systems mirror basic processes of fetal brain development such as proliferation, migration, differentiation, and apoptosis.
Recent work encompassing both functional neuroimaging and studies of brain-injured patients—suggests that these 2 basic processes of semantic cognition, semantic representation and control, are underpinned by distinct areas in the human brain.
This questionnaire measures 10 basic processes of change.
Figure 3 Basic process of pattern matching.
The basic process of splicing is conserved among eukaryotic species.
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