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Dr. Bloch "laid out the basic pathway, and we wanted to see how that pathway was turned on and off," Dr. Brown said.
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The recent description of Drosophila haematopoietic stem-like cells and their niche – and the accumulating evidence that many of the basic pathways and processes are also present in vertebrates – establishes Drosophila as a model for studying the genetic aspects of haematopoiesis and haematopoietic disorders.
The role of epigenetics in the regulation of gene expression has been considered as a basic pathway in the progression and pathogenesis of various malignancies, such as cancers of the urogenital organs.
This basic pathway can be stimulated by mood stabilizing and antidepressant drugs, by either direct inhibition of GSK3β or upstream activation of ERK and AKT.
Therefore, in our analysis we map genes to the pathway nodes and assume the node as the basic pathway unit.
Trypanosomatid PRORP1 differs from any previously characterized nuclear RNase P. Still, the basic pathway of tRNA processing seems preserved in T. brucei, and like in yeast (Walker et al., 2010), 5′ end maturation primarily occurs in the nucleolus.
For us, for now, the dream is simply to keep our feet moving, step by step, along the basic pathway to eventual success.
Nitrogen metabolism is a basic pathway that maintains the balance of nitrogen in organisms.
Remarkably, this basic pathway can explain most of the characteristic features of polyQ diseases that are due to polyQ expansion.
These data suggest a common basic pathway of macrophage activation genes in multiple tissues of Gba1 mutated mice.
Matching those basic pathway components leads to matching specific reactions with over 3.5 K (out of ca. 8 K) reactions from Reactome mapped to their Kegg counterparts.
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