This basic observation has been one of the central struts of my belief system for a long time.
This basic observation had been made previously by others in the context of miR-103 and miR-107 precursors [37] in mice tissues.
Similar observations have been made for an orientase hydrolysate with considerable ACE-I inhibition attributed to its high basic and aromatic amino acids contents [ 30].
Similar observations have been made about the medical profession.
Similiar observations have been reported by [41].
These observations have been largely made using muscle sections however, which makes it is extremely difficult, if not completely impractical, to examine all myonuclei in a given myofibre: the basic functional unit of skeletal muscle.
Both observations have been reported.
"Observations" has been hard to find ever since.
These basic observations have blossomed into our general understanding of cancer.
To reconcile the previous observations, several mechanisms for internalisation of basic peptides have been proposed which include different types of endocytosis, "electroporation-like", inverted micelles, and pores formation [8], [9].
