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GPCR pharmacology has benefited enormously from the application of fluorescence-based technologies and we now possess a much greater understanding of this receptor family's basic molecular mechanisms of action through the careful design and judicious use of fluorescent peptide and small-molecule-based ligands.
MSC-based cellular therapy has the potential and opportunity to effectively combat OA, but more extensive clinical trial and animal studies are required to understand the basic molecular mechanisms of MSC dependent cartilage regeneration.
Furthermore, this experimental model of a rapid induction of senescence in immortalized cells provides a reproducible and practical approach for future studies on basic molecular mechanisms of ageing and on testing potential interventions.
The success of such drugs has fueled a push toward studying basic molecular mechanisms of cancer growth, which has brought with it "a crush of data so large that no human brain alone would be able to make heads or tails of it," says Levi Garraway, assistant professor of medicine at the Dana-Farber Cancer Institute in Boston, Massachusetts.
I can barely remember these feelings, but when I started my research career, I wanted to fundamentally and positively affect the human condition through discovering basic molecular mechanisms of diseases.
Other aspects students indicated as positive were the clinical contextualization of basic molecular mechanisms of hormonal regulation, and the improvement on skills related to literature database search.
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Understanding mechanisms of memory enhancement will contribute to elucidate the basic molecular mechanism of learning and memory as well as to the development of treatments for cognitive disorders.
The discovery of characteristic sequence motifs using SNP arrays is also important in a more general context: DNA/DNA duplex formation is the basic molecular mechanism of functioning not only of SNP arrays but also of other array types such as re-sequencing [2] and different expression arrays (gene- or exon-related and whole genome tiling arrays) of newer generations.
The basic molecular mechanism of circadian rhythm has been studied extensively.
However, the basic molecular mechanism of hepatocarcinogenesis remains unclear (Buendia, 2000; Durr and Caselmann, 2000).
All of this may improve our understanding of the basic molecular mechanism of BRCA1-related ovarian cancer.
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