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In the three-dimensional structure of P8, these side-chains cluster into three functional epitopes: a hydrophobic epitope located near the N terminus and two epitopes (one hydrophobic and the other basic) located near the C terminus on opposite faces of the helix.
The hotel was real basic, located between second hand car dealerships and discount rug and tile stores.
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After identifying the multiple CTQ characteristics of machining process it is deduced that the CTQ characteristic of prime importance is the Center Bore hole diameter of ø50.000 (±0.050), as this CTQ dimension forms the basic locating dimension for further machining operations, mainly the drilling of pitch circle diameter holes and any deviations of it leads to bottleneck.
In the case of mutant K285E, the replacement of a basic amino acid by an acidic one masks the basic patch located in this area.
The basic region, located at the N-terminal end of the domain, consists of 13 17 primarily basic amino acids and is involved in DNA binding.
From the matrices shown in Fig. 4, we picked up cells that represented pairs of basic units located at identical positions in different HOR units (e.g. the second basic repeat unit in the third HOR unit and the second basic repeat unit in the fourth HOR unit).
Monopartite NLSs, exemplified by the SV40 large-T antigen, have a single cluster of 4 5 basic residues (e.g. P KKKRKV), whereas bipartite NLSs, such as that of nucleoplasmin, have a second basic cluster located 10 12 residues downstream from the first cluster (e.g. KRPAATKKAGOA KKKLD).
There are 50% more basic sites located on these Na secondary phase as compared to un-doped system.
The proteinase possesses two characteristic surface areas enriched in basic residues located far from the catalytic centre, termed anion-binding exosites.
Conversely, RanBP1 stabilizes the HEAT-9 loop in its inward conformation through interactions mediated by three basic residues located in RanBP1 strand 1 and in the β3β4 loop.
It should be noted, however, that E431 lies within a cluster of basic residues located on the surface of the redox partner binding site of CYP21 [34].
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