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FGF-2 was originally identified as a basic growth factor which stimulates the proliferation of NIH-3T3 fibroblasts.
In this study, we investigated the effects of five exogenous growth factors known to be expressed by gliomas [epidermal growth factor (EGF), basic growth factor (bFGF), transforming growth factor beta (TGF-β1,2) and vascular endothelial growth factor (VEGF)] on MMP-2 and MMP-9 expression in an ependymoma, two grade III astrocytomas, a grade III oligoastrocytoma and a benign meningioma.
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33 It has been reported that phosphotyrosine phosphatase DEP-1/PTPη-dependent dephosphorylation of ERK1/2 is required for inhibition of basic growth factor-dependent cell proliferation mediated by the stimulating somatostatin receptors in glioma cells.
Expression of basic fibroblast growth factor (basic FGF), FGF receptor and VEGF was found at higher levels in stroma of phyllodes tumors in comparison with fibroadenomas [ 24].
There was no correlation of basic fibroblast growth factor staining with either serum basic fibroblast growth factor levels or microvessel count.
The aim of this study was to evaluate whether non-Hodgkin's lymphoma cells express basic fibroblast growth factor and/or its receptor (fibroblast growth factor receptor-1) and whether basic fibroblast growth factor expression correlates with basic fibroblast growth factor serum levels, intratumoral microvessel density, and patient outcome.
Human basic fibroblast growth factor.
Basic fibroblast growth factor (bFGF) stimulates neoangiogenesis.
Basic fibroblast growth factor 2. Standard error of the mean.
Basic fibroblast growth factor (bFGF) was used as a control.
WJMSCs treated with a mixture of glial growth factors (basic fibroblast growth factor, platelet-derived growth factor and forskolin) adopted a spindle-like morphology similar to SCs.
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