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Compound 18e, which had a guanidino group at the P2′ position as the basic functional group, exhibited broad inhibition against target enzymes for a relatively long period in rat plasma (β t1/2; 2.0 h) after sc administration when compared with compounds possessing acidic functional groups (18a and 18b).
Chemical modifications of the basic functional group (primary and secondary) to a neutral species (e.g., conversion of primary amine to a substituted urea or amide) may impede the entry of the NME into the CNS.
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As a result, the 7021 DEGs were categorized in three basic functional groups: molecular function, biological process and cellular component groups.
Subsequent regeneration leads to the formation of basic functional groups which limit this enhanced adsorption.
Ion exchange resins are polymers which contain acidic or basic functional groups able to exchange counter-ions.
All adsorbent samples indicated the presence of basic functional groups and thus the potential to act as MB adsorbents.
We have recently designed potent and isoform selective inhibitors of nNOS, but the lead compound contains several basic functional groups.
Propylene oxide can be selectively transformed into propylene carbonate (selectivity: 99+%) in the presence of ion exchange resin catalysts with basic functional groups.
They reported that a combined effect of carbon surface chemistry (high basic functional groups and low acidic groups) and carbon porous characteristics were responsible for the NO3− adsorption.
Compounds with acidic and basic functional groups (aspartic acid, arginine, and cystine) are evaluated for inhibition of aldol condensation and dissolution of product in alkaline media.
At this value, the acidic or basic functional groups no longer contribute to the pH of the solution (ApteSagar et al. 2011).
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