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At the same time, the basic discoveries in cell biology, including embryonic and adult stem cells, induced pluripotent stem cells, genetically modified cells and others, have moved regenerative medicine into the center of biomedical research worldwide with a major translational impact on tissue engineering as well as transplantation medicine.
As predicted by Matthew Freeman and Daniel St Johnston in their inaugural editorial entitled Wherefore DMM? (Freeman and St Johnston, 2008), the application of basic discoveries in model organisms has accelerated the study of human disease in recent years.
The formation of both the outer epithelial barrier and the inner intestinal barrier depends on the formation and maintenance of intercellular junctions, and many basic discoveries in this field have been made in Drosophila (Banerjee et al., 2006; Furuse and Tsukita, 2006; Wirtz-Peitz and Zallen, 2009).
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A. We feel a real responsibility to pay attention to the right balance of basic discovery in the laboratory — genetic and molecular findings — while at the same time making sure we can translate those findings into new approaches that can make a difference.
A central dilemma in medicine and public health is the translation of basic discoveries into clinical practice and population health.
In fact, he believes, industry funding is vital for translating basic discoveries into clinical therapies.
As Childe remarked, these depended on the same basic discoveries as those exploited in Egypt or Mesopotamia, but in each case the crafts acquired a significance of their own.
Embryonic stem cell science may optimistically be characterized as moving across the T1 valley from basic discoveries to initial applications in health – though even recent developments, such as the report of the first cloned human stem cells[20], remind us that basic science work continues in this field.
The lipoprotein nanoparticle field has benefited from extensive history of basic discoveries stemming from research in cholesterol metabolism.
This contributed to creating momentum and renewed interest in basic discoveries related to the transport of water and indirectly to diabetes insipidus [ 57, 58].
Results obtained from rodent studies are useful but, due to the anatomical, molecular and functional differences, confirmation of these findings in large animals or non-human primates may lead to basic discoveries that cannot be made in rodent models and that are more useful for developing treatment strategies in humans.
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