The results will be relevant to understanding the mechanisms of metal handling by biological systems and the basic cellular roles underlying the nutritional requirement for essential metals.
The glycans, then, either have a cellular role such as localization or they are simply fortuitous.
Most helicases are members of DEAD-box protein superfamily and play essential roles in basic cellular processes such as DNA replication, repair, recombination, transcription, ribosome biogenesis and translation initiation.
Small GTPases play important roles in basic cellular processes such as cell proliferation, invasion, chemotaxis and adhesion [ 24].
CoA is synthesized from vitamin B5, or pantothenate, and plays key roles in basic cellular functions such as fatty acid metabolism, Krebs cycle and amino acid synthesis.
Most helicases are members of the DEAD-box protein superfamily and play essential roles in basic cellular processes such as DNA replication, repair, recombination, transcription, ribosome biogenesis and translation initiation [ 50].
Most helicases are members of the DEAD-box protein superfamily and play essential roles in basic cellular processes such as DNA replication, repair, recombination, transcription, ribosome biogenesis and translation initiation [ 59, 61].
p600 is a multifunctional protein with key roles in basic cellular processes such as protein degradation (ubiquitin/proteasome-mediated degradation or autophagy), cell adhesion, cell survival and anoikis (a form of apoptosis induced by cell detachment).
Due to all of these functions, HA plays regulatory roles in basic cellular behavior, such as cell adhesion, cell migration, cell-cell recognition and cell differentiation [ 7, 8], and thus participates in many important processes of morphogenesis, tissue remodeling, inflammation and several types of diseases, such as tumor growth and atherosclerosis.
Therefore, we investigated the key signalling pathways, PI3K/Akt and MAPK/ERK, which are involved in AP-1 activation [30], [31] and play a pivotal role in basic cellular functions such as cell growth, survival, migration, angiogenesis and tumorigenesis [28], [29], [42].
