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As expected, these included genes for mobility of DNA fragments but, interestingly, also genes associated with basic cellular mechanisms such as translation and regulation of transcription and transduction.
Analyzing genes harboring hyper-DMRs in their respective promoter regions by Gene Ontology (GO) analysis (Biological process, level 5) revealed an enrichment of basic cellular mechanisms, such as RNA metabolism, regulation of transcription, cellular biosynthesis, nucleobase, nucleoside, nucleotide and nucleic acid metabolism, macromolecule biosynthesis and transferase activity (FDR, p < 0.05).
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The three researchers independently unraveled basic cellular mechanisms several decades ago in Schekman's case, almost 40 years ago.
Trained as a mathematician, his work focuses largely on biological probabilities -- applying mathematical and statistical analysis to complex cellular mechanisms, such as protein strings.
Although these oscillations have been commonly indicated to involve the thalamus their basic cellular mechanisms remain poorly understood.
In conclusion, here we use high throughput screens in yeast to elucidate the basic cellular mechanisms mediating binaphthoquinone cytotoxicity.
However, the basic cellular mechanisms regulating chondrocyte responses are very different in OA and RA.
Tumorigenesis involves many fundamental alterations in basic cellular mechanisms and interactions with microenvironment.
Key challenges are to better understand basic cellular mechanisms involved in kidney stone formation and to identify novel cellular markers for key pathophysiological processes during kidney stone formation.
Our understanding of basic cellular mechanisms regulating chondrocyte responses to inflammatory cytokines has been inferred from numerous studies in vitro with cultures of cartilage fragments or isolated chondrocytes and is supported by studies in experimental models of inflammatory arthritis such as collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA) in mice.
Cancer cells have evolved strategies to counteract these basic cellular mechanisms to deregulate the cell cycle and facilitate either cancer cell growth or to evade cell death.
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