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It was also reported that miRNAs predominantly target positive regulatory motifs, highly connected scaffolds and most downstream network components such as signaling transcription factors, but less frequently target negative regulatory motifs, common components of basic cellular machines and most upstream network components such as ligands [ 32].
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Network motifs represent the simplest building blocks of cellular machines and are of biological significance.
A comparative genomics approach to the entire cellulome may reveal the diversity of cellular machines and their inter-relationships.
Transcription factors are master regulators in orchestrating basic cellular behaviors and are responsible for critical cellular functions and cellular fate.
Cilia-dependent signaling affects very basic cellular functions and aspects including cellular polarity and cell cycle progression [1-3].
This will improve our understanding of viral pathogenesis and provide insights into basic cellular and immunological processes.
It also faced stiff competition from local players such as TCL and Ningbo Bird, whose basic cellular telephones targeted midtier cities and midmarket and low-end customers.
It can serve as cellular machines, rigid structures, and posttranslational modification systems.
High and Medium High brackets mostly related to cell structure and basic cellular biology functions, respectively.
and (ii) how does evolutionary change modify cellular machines while maintaining their fundamental structure and function?
One could use this information to design more efficient anti-cancer drugs or manipulate basic cellular functionalities such as cell reproduction and metabolism to slow down aging process.
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