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This work clearly implicates EphB4 as a major regulator of the basic cellular function of endothelia and highlights the need for further investigation into the specific pathways by which it functions.
We reasoned that an interaction of BRCA1 with a conserved yeast protein(s) interferes with a basic cellular function essential for yeast survival and that these proteins would be intimately involved in the maintenance of genomic integrity.
The basic cellular function of myosin motor is to deliver ATP-dependent force impulses to the rope-like actin polymer.
Genes with large epistatic effects interact strongly across the genome and tend to be involved in basic cellular function and maintenance (supplementary table S3, Supplementary Material online).
In some studies, gene expression and basic cellular function of such ALI cultures were shown to resemble those found in vivo in intact bronchial epithelium [ 1, 17].
These genes have been referred to as housekeeping genes (HKGs) and are hypothesized to constitute a small set of genes required to maintain minimum basic cellular function [ 1].
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Indeed, over-represented functional classes of constitutively expressed genes are mainly basic cellular functions, expected to be active in each cell type, such as metabolism or gene expression related functions.
Other genes present are involved in basic cellular functions such as acetyltransferases, involved in posttranslational modifications of ribosomal proteins, the functional significance of which remains unclear but may have regulatory roles (Nesterchuk et al. 2011).
Defective mitochondria are swapped out for healthy ones, but mitochondrial DNA governs only a handful of basic cellular functions.
Researchers have discovered how mutations in genes required for basic cellular functions give rise to face-specific birth defects.
Hence PREP1 is not, or not only, a developmentally essential gene, but it also controls basic cellular functions, like DNA replication timing.
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