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Genes with decreased expression were mainly involved in basic cellular activities and the associated regulatory infrastructure, such as RNA processing and splicing (fibrillarin, PNP1ase), translation (eIFs, NOP56, RPSOB), morphogenesis (expansins, nodulins, cell wall proteins), or essential metabolism genes, e.g., during nutrient-induced reprogramming [118].
Conserved genes are involved in basic cellular activities and thus are required for all stages.
Here, we identify basic cellular activities connected to translational control of gene expression as sufficient to specify auxin-mediated development.
The study illuminates the integration of small RNA related pathways with other basic cellular activities that govern gene expression for different cellular actions.
The protein kinase family is one of the largest protein families in human, comprising 518 different kinases that function as on/off switches in cellular signaling pathways and modulate almost all basic cellular activities.
Although no definitive function for vault particles has yet been determined, their evolutionary conservation and high abundance suggest that they are involved in one or more basic cellular activities.
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There are different types of deformations (e.g folding, rolling or spreading) that contribute to different morphogenetic processes, but they all rely on changes at the single cell level, which result from the activity of basic cellular processes: cytoskeleton activity, cell adhesion and intracellular trafficking.
Many of these therapies focus on proteins that are involved in cell signalling pathways, which form a complex communication system that governs basic cellular functions and activities such as cell division, cell movement, how a cell responds to specific external stimuli and even cell death.
Disorganization of basic cellular architecture can affect activities ranging from cell signalling and migration to cell cycling and apoptosis.
While further studies are needed to better determine the role and cellular activities of BASIC, the study suggested that it may act as a factor in the therapeutic effects provided by UDCA.
Many of these processes were over-represented in both the in vitro and field graft transmitted genes, covering various basic cellular, biosynthetic, catabolic, and metabolic activities.
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