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Further characterization of the genome-wide transcriptional programming of the mammalian cell cycle is a critical step toward understanding the basic cell cycle processes and their precise roles in cancer.
The same is true for genes involved in basic cell cycle machinery [ 49].
However, we still do not understand why loss of RB function leads to cell cycle re-entry in only specific cell populations, highlighting the need for more basic cell cycle research.
The starting set of parameter values for the optimization, produced by manual tuning, captured the basic cell cycle characteristics of wild type cells as well as the phenotypes (viable or inviable) of ∼60% (72 out of 119) of the genetic strains.
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By comparison, kinetoplastids possess the CDK/cyclin system, cohesin complex, separase, condensin complex, Aurora B, the anaphase promoting complex (APC/C), and proteasomes, suggesting that the most basic cell-cycle machinery is conserved in these distant eukaryotes (Akiyoshi and Gull, 2013).
Those genes regulate basic functions of cell cycle such as proliferation, apoptosis, and DNA repair.
It is possible that the same basic defect in cell cycle regulation might lead simultaneously to BFB instability and mitotic multipolarity.
I compare phenotypic differences in nematode embryogenesis in two basic cell biological processes, the cell cycle and the localization of the first division axis.
A major difference between stem cells and somatic cells is found in the basic regulation of the cell cycle.
Nevertheless, tumor cells must still adhere to the basic tenets of the cell cycle program to ensure their survival by DNA duplication, chromosomal segregation and cytokinesis.
The fission yeast, Schizosaccharomyces pombe, over the last decades has emerged as a valuable model organism in understanding basic biological mechanisms, especially the cell cycle and chromosome biology.
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