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Scientific advances gained by transgenic capabilities enable further understanding of basic biological pathways and yield insights into how changes in fundamental processes can perturb programmed development or culminate in disease pathogenesis.
The study demonstrated how integrating GWAS data into functional genomic, model organism and clinical information can uncover basic biological pathways that are associated with disease outcome.
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MicroRNAs (miRNAs) are noncoding nucleic acids able to regulate basic biological functions and pathways essential to tumor development and progression [ 1].
As part of the Cancer Drug Discovery and Development series, this book aims to explain basic biological processes and signalling pathways and to link that knowledge to the anticancer drugs associated with those pathways.
Because of differences in the development and lifespan between humans and mice, one may certainly argue that significant differences exist in the timing of gene expressions, but the basic workings of molecular and biological pathways have been shown to be similar, if not identical.
Basic biological systems including gene sequences, structures, and pathways that direct metabolism and development—vary within individuals, among individuals, among populations, and among species.
However, the lack of iron as a cofactor in many of the basic biological processes results in a multitude of biological pathway failures, resulting in chlorotic plants.
Here, we use a generic mathematical model of biological pathways, which captures their basic properties.
In many organisms, natural isolates have been a source of variation for the analysis of pathways and processes of basic biological interest.
Canonical pathway analysis identified the biological pathways of most significance.
Besides the importance of this pathway as a tool in basic biological research, unraveling its structure and regulation is also of major medical importance.
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