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The ability to genetically manipulate bacteria has been fundamentally important for both basic biological discovery and translational research to develop new vaccines and antibiotics.
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By investigating the effects of compounds on the biological pathway network, researchers can easily evaluate the potency of compounds and thus move basic biological discoveries into the clinic applications.
Remember, if you are speaking in terms of drug development based on basic biological discoveries, it takes about 12 to 15 years from the time you make a discovery until you have a drug on the shelves.
Many of the failures we have seen in translating novel basic biological discoveries to useful medicines are a result of the inadequacies of the animal models we use at the critical juncture between bench and bedside.
Short hairpin RNA (shRNA -induced RNAi ishRNA -inducedlogical discoveRNAind therapeutiss.
Genome-scale models of microbial metabolism are increasingly being used in biological discovery and metabolic engineering.
Research on RNA has led to many important biological discoveries and numerous Nobel Prizes.
DOI: http://dx.doi.org/10.7554/eLife.04885.002 Development of human in vitro systems for basic biological studies and drug discovery is motivated by the need to improve outcomes in human patients and alleviate ethical considerations demanding a reduction in the use of animals (Dambach and Uppal, 2012; Bhatia and Ingber, 2014).
Since their development in the early 1990s, differential gene expression (DGE) technologies have been applied to a multitude of biological challenges, both for the purpose of basic biological research and as a valuable tool for the discovery and development of pharmaceuticals.
Since their development in the early 1990s, differential gene expression technologies have been applied to a multitude of biological challenges, both for the purpose of basic biological research and as a valuable tool for the discovery, validation and development of pharmaceuticals (25).
The basic biological and physiological knowledge did not correlate with self-assessed basic competence.
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