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In the "Biological background" section we shall review the basic biological data, and in the section "Genomic instability and somatic cellular Darwinian evolution in cancer" we shall examine the evidence for GI as an initiating event in cancer.
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For Chilean native freshwater fish, basic biological data is scarce and data on 7-ethoxyresorufin-O-deethylase (EROD) and Acetylcholinesterase (AChE) activity is practically absent.
A unique aspect and challenge to epidemiologic studies involving wildlife relates to the need to integrate the collection of both disease and basic biological data [ 21].
He needed a lab – the special fridges, microscopes and chambers to study the island's insects, and develop basic biological data on viruses circulating in the country.
Enriching basic biological data with higher-level functional annotations and facilitating specialized analyses in organized workflows enables extraction of higher-level knowledge.
However, even for these species, significant uncertainties exist in the basic biological knowledge and data.
Gene expression data from isolated cell types can be used to address questions of basic biological relevance and for pharmacological research or biomarker development.
The data obtained from RNA-seq projects are also helpful in inferring the basic biological, molecular, and cellular processes [ 19, 20].
Such developments are necessary, in order to deal with high-throughput data reliably allowing to connect basic biological and medical research programs [ 60].
This disparity reflects the current relationship between basic biological science and its use for therapeutic purposes.
L.C. and M.P. contributed to biological data collection and analysis.
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