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The challenge is for clinician-scientists to integrate basic and translational advances efficiently and rapidly into the clinic, recognizing the value of a multifaceted paradigm.
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The past 2 years have seen a number of basic and translational science advances in the quest for development of an effective HIV-1 vaccine.
Secondly, with almost daily and exponential advances in basic and translational research findings, novel cancer drugs and cancer preventive and therapeutic strategies are designed yet not tested because of a contracting patient pool available and willing to participate in clinical trials [ 15, 16].
Lastly, we present a provocative view of the clinical relevance, emerging challenges in dual targeting of redox and autophagy pathways for therapy, and the future directions to be addressed in order to advance both basic and translational aspects of this field.
Therefore, a better characterization of the biological and molecular processes and of the networks of interactions involved in regulation of RMS gene expression would represent a considerable advance in basic and translational research regarding this tumor.
Significant advances in both basic and translational research have enhanced understanding of myeloma pathogenesis and prompted to test new and more effective molecules as therapeutic targets (Mitsiades et al, 2009; Anderson, 2011).
There is thus a crucial need for a proper balance between basic and translational research to adequately feed the scientific pipeline for advancing public health.
Numerous advances, including the discovery of novel diseases, have been made in recent decades through clinical, basic, and translational research.
Basic and translational research is typically funded by the government.
This can happen in both basic and translational research settings.
Open image in new window Figure 2 Applications of organoid technology in basic and translational research.
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