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Begley, C. G. & Ioannidis, J. P. Reproducibility in science: improving the standard for basic and preclinical research.
Emphasis on basic and preclinical research in selected categories of neurological disease, and understanding how these discoveries are being translated into therapies.
Intensive basic and preclinical research is clearly needed and should proceed, subject to appropriate legal and ethical rules and oversight, on (i) technologies for editing genetic sequences in human cells, (ii) the potential benefits and risks of proposed clinical uses, and (iii) understanding the biology of human embryos and germline cells.
Short of "experiments involving human embryos," he said, the forum's organizing committee believes that "intensive" basic and preclinical research on genetic editing "is needed".
The bipolar cells, which are post-synaptic to the photoreceptors, are important retinal targets for both basic and preclinical research.
On the basis of more than 50 promising basic and preclinical research studies [ 3], we began arthroscopic transplantation of autologous synovial MSCs for cartilage defects in the knee.
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Mouse models provide an excellent resource for study in both basic science and preclinical research.
Multimodality reporter-gene imaging using coexpressed luciferase/fluorescent proteins and HSV1-tk has been reported to be a powerful tool for basic biological and preclinical research.
These studies involve design, synthesis, mechanistic biology, and preclinical research.
In this role he successfully raised funds and carried out several clinical and preclinical research projects.
In recent years, several groups have presented combined PET/MRI devices for clinical and preclinical research.
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