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Among the various basic and clinical applications for ES cells, cell transplantation therapy for central nervous diseases is of particular interest because differentiated neurons do not proliferate, and a relatively large number of donor cells are necessary to replace diseased neurons.
Therefore, possible immunological rejection or religious and ethical concerns greatly hinder the pace of ESCs in basic and clinical applications.
Although PCR was developed only a few decades ago, it has found numerous basic and clinical applications and is indispensable in today's science.
This may indicate the possible use of Eif1a-like genes as potent repressors of the global protein synthesis in basic and clinical applications.
Our studies uncover a novel link between GRP78 depletion and reduction in cytosolic ubiquitination and establish a novel mouse model of accelerated cerebellar degeneration with basic and clinical applications.
However, the spontaneous generation of INS+ cells from ES cells happens at a low rate, and most of these induced cells show limited glucose-stimulated insulin secretion (GSIS), which is limited in basic and clinical applications.
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Thus the opportunity for basic and clinical application of functional cells derived from the full range of pathological breast tissue, instead of a few immortal cell lines should not be missed.
Among them, superparamagnetic iron oxide (SPIO) nanoparticles have a great potential for basic and clinical application due to their several advantages, such as guided transport or distribution under an external magnetic field in vivo and T2-type magnetic resonance imaging contrast enhancement [ 3, 4, 6– 10].
Moreover, the implications of ISS knowledge for basic neuroscience and clinical applications are addressed.
Future work will reveal if the approach of epigenome editing fulfills its great promise in basic research and clinical applications.
Delivering genes to mediate functions of cells is a crucial technology for both basic science and clinical applications.
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