A family tendency to hypertension has been found in persons with the disease, and there may be a basic genetic abnormality involving the permeability of cell membrane in the blood vessels.
For example, is Ocrl1 a protein with two distinct functions or are these phenotypes different manifestations of the same basic functional abnormality?
They contrasted their results in normal men with those in HTG patients, in whom abnormalities of lipid and glucose metabolism frequently occur together, suggesting that these may not be causally related but rather separate manifestations of a more basic underlying abnormality (Anderson et al., 1973).
The basic cellular abnormality in FA has been postulated to lie in the DNA repair mechanisms, because cells from FA patients display chromosomal abnormalities and are hypersensitive to agents that cause DNA interstrand crosslinks (ICLs), such as mitomycin C (MMC) and CDDP [ 14].
While basic haematological abnormalities have not been previously reported in CFS/ME in relation to FBC, ESR, CRP and electrolytes, immunological abnormalities have been increasingly documented in cases of CFS/ME.
We focus on peer-reviewed studies of AN and BDD that address ophthalmologic abnormalities, basic neural processing of visual input, integration of visual input with other systems, neuropsychological tests of visual processing, and representations of whole percepts (such as images of faces, bodies, and other objects).
Furthermore, abnormalities in basic motor control, skilled motor gestures, and motor learning, are common in ASD.
Due to abnormalities in basic bone building components (collagen and mineral), the intrinsic material properties of Osteogenesis Imperfecta (OI) bone were hypothesized to be degraded and correlated to clinical types.
