In the ICU setting, there is instead a considerable advantage in blood sampling, allowing for serial measurements, reducing the risk of making an erroneous decision based on one single sample.
A whole-genome view of aberration frequencies (based on single sample PCF) and highly correlated aberrations (based on multi-sample PCF) are shown in Figure 6.
According to an estimate based on single sample sequencing, it would require coverage of at least 20X to detect 99%% of the heterozygous variants [ 55].
Our analysis is based on single sample of Spanish patients receiving a variety of treatments within the broad spectrum of standard practice.
The present task was based on single sample exposures while the operant box task required 39 sessions, each with multiple trials, for the rats to acquire the rule, reinforce if A occurs before B but not if B occurs before A. The underlying goal was to determine the extent to which anterior thalamic lesions mimic the impact of hippocampal lesions in rats.
An unbalanced nested sampling design, based on single samples, was implemented at Walcheren/Zuid-Beveland, an agricultural area in the south-west of the Netherlands.
Results from a serologic survey based on single samples from each study participant, as in Ceará, will necessarily have much wider CI.
It is increasingly clear that GWA efforts based on single samples will not succeed in identifying replicable genetic variants, especially if the majority of genetic variants have very small effect sizes (cf. Luciano et al., 2013; Meaburn et al., 2008).
Although 'snapshots' of genetic patterns based on single samples can be extremely informative, the ability to divulge historical population processes that shaped current patterns of genetic variation is limited (Beaumont 2003; Miller and Waits 2003).
