Sentence examples for bases of their binding from inspiring English sources
In addition, in yeast, activation sites appear to be restricted by chromatin-mediated mechanisms to act within a few hundred bases of their binding site (Dobi and Winston 2007).
Structural analysis of a large number of intrinsic disorder-based protein complexes resulted in another categorization of IDRs based on their binding plasticity.
Previously, we also proposed a Kolmogorov Smirnov test like method to infer activity changes of TFs based on their binding association with sorted expression profiles [ 24, 25].
From this, we propose a classification of PPI stabilizers based on their binding mode and the architecture of the complex to facilitate the structure-based design of stabilizers.
The above-described limitations probably outline the major pitfall of the phage display technique that complicates the selection of "true" mimotopes, solely based on their binding characteristics to mAbs.
Several methods have recently been developed to select members of random peptide libraries based on their binding affinity to known protein targets [ 13].
The interfaces can then be clustered, based on the clustering of their binding sites.
We identified the interacting pair(s) of transcription factors (TFs) based on the spatial proximity of their binding sites.
Based on over-representation analysis of their binding sites we find that the expression pattern for the genes of these six transcription factors correlate nicely with the time profiles of their putative target gene clusters.
ELISA data are presented as heat maps in which antibodies are grouped based on a hierarchical clustering analysis of their binding specificities against a diverse set of plant glycans [ 29].
ATF6, a protein of interest to us, was predicted to be regulated by three of the upregulated miRNAs - miR-145, miR-221 and miR-494 (Figure 1). Figure 1A depicts the full-length human ATF6 3′UTR with predicted binding locations for miR-145, miR-221 and miR-494, and Figure 1B shows the locations and base pair matches of their proposed binding sites, adapted from TargetScan 6.2.
