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Forcing coevolution between known pairs of sites in simulated MSAs built on the bases of the evolutionary and physico-chemical properties of real proteins allows a better understanding of the power of methods designed for such purpose.
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Considerable theoretical literature exists on the evolution of mutation rates based on the evolutionary fate of mutators [ 11, 12, 51].
We now turn to the problem of training a classifier to predict the fate of a human site based on the evolutionary history of its surroundings.
Based on the evolutionary conservation of genomes of related organisms, the construction of a phylogeny, known as phylogenomics, can be carried out.
In soybean, we were able to distinguish between two types of duplications and clusters based on the evolutionary history of the TF-coding genes that they contain.
Yet acclimation itself is under evolutionary pressures, and limits of acclimation are often based on the evolutionary history of the species and population (Meester 1996; Stillman and Somero 2000; Calosi et al. 2010).
Garbelotto said other scientists have hypothesized that gene regulation has an effect on plant pathogens, based on the evolutionary rates of portions of the genome that are known to have an effect on gene regulation.
Here we introduce a new methodology to detect coevolving groups of sites within a molecule, based on the evolutionary history of these sites.
The chapter discusses the shape optimization design of a prestressed cable-truss structure based on the evolutionary method of nodes.
Each of these methods assigns a conservation score to each site i, based either on the evolutionary history of that site alone (in the case of GERP, LRT and SCORE) or based on the evolutionary history of site i and its surrounding sites (in the case of PhastCons).
Two types of duplications and clusters can be distinguished based on the evolutionary history of the genes that they contain.
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