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Due to lack of further characterization of these identified enzymes, their mechanisms of catalysis and the molecular bases of substrate recognition remain unclear.
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Title Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition.
Johnson, Z. L. & Chen, J. Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.
The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT.
Here, we integrate structural, biophysical, and modeling approaches to identify the hitherto unknown substrate-binding site in TRiC and uncover the basis of substrate recognition.
These results offer insights into the molecular basis of substrate recognition for the BmaI1 enzyme.
The classification of a hemicellulose-oxidizing LPMO [ 1] into subfamily 3 together with a cellulose-oxidizing LPMO [ 5, 7] does not point to a clear division of the LPMOs based on substrate recognition.
Our results suggest ways of developing other MMP inhibitors based on substrate recognition sites that may provide greater levels of inhibition.
Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein.
Although APE1 incises DNA at DHU and αdA lesions in the same manner, we suspect that the mechanism of substrate recognition by APE1 for these two distinct base lesions might be quite different.
Based on our findings, we propose metabolic systems for each substrate and molecular models of substrate recognition system in C. cellulovorans.
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