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The most obvious difference is the increased resolution of the SVM and PhyloP approaches, which evaluate each base independently (though in the context of the two flanking bases in the case of SVM), compared with the HMM-based approach of PhastCons, which produces much smoother estimates.
In nucleic acids and proteins, the individual chemical units -- nucleotide bases in the case of DNA and RNA, and amino acids in the case of proteins -- are all linked by the same type of chemical bond.
Just as I'd advise anyone planning to be married to cover their bases in the case of divorce, for anyone considering employing a surrogate with their spouse, Shepherd's case can serve as a primer for the scenarios they ought to consider -- and to address ahead of time.
This result shows that the SELEX system selects specific bases; in the case here, and as reported [1], AT-rich sequences.
Analysis of gene models predicted from assembled EST and full-length cDNA genomic alignments from rice and Arabidopsis discovered that many alternative splicing sites are separated by a small number of bases, typically four or three bases in the case of alternative donor and acceptor sites, respectively [ 12].
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This process was based, in the case of paired nucleotides, on mutating the complementary nucleotides as well.
The coupling reactions were carried out in dry DMF with KHCO3 as a heterogeneous base in the case of 28 and N, N-diisopropylethylamine (DIPEA) as a base for the other nucleotides 29– 31.
"What better guy can teach our players how to steal bases, and in the case of José Reyes, how to be a leadoff hitter?" General Manager Omar Minaya said.
McArdle's disease was suspected on clinical bases in the index case (P1).
The equilibrium favours the weaker acid and base, in this case the products.
A third function is to reduce the temperature of the base metal in the case of thermal barrier coatings.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com