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The proposed two stage setup deviated from the baseline workflow only for a small set of patients.
They were combined to describe the baseline workflow at the ANC clinic as detailed in Table 1.
We compared our proposed method with the baseline workflow, where most patients are treated with DES, by estimating adverse effects and costs similar to outlined above.
In the baseline workflow, all patients are treated with DES except patients with 3-vessel disease, for whom the SYNTAX trial concluded that CABG would be an appropriate alternative to PCI [ 1].
We found that the proposed two-test setup resulted in an increased estimated effectiveness as well as lower estimated costs when compared to the baseline workflow in all settings.
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The overall costs decreased by 3.8%9595% CI, 2.7 to 5.3) and 4.0% (95% CI, 2.9 to 6.4) per patient, compared to the baseline treatment workflow.
The averaging and normalisation of the control group was performed using the baseline creation workflow in CONTRA (Li et al, 2012).
In another data procession workflow, baseline-subtracted fluorescence ratios, which were determined in a way similar to the above mentioned linear regression method, were also provided as Supplementary Material 4, 5,6 [see Additional file 4, 5, 6].
A fundamental aspect unique to tiling array data analysis workflow was defining the baseline for the identification of expressed regions of the genome.
To maximise the chances of detecting the low-amplitude time-lapse signal we optimise the current time-lapse processing workflow using synthetic datasets for the entire baseline and monitor surveys.
The workflows have been identified, along with a baseline architecture for the data management infrastructure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com