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The current trial only includes patients with an increased CIMT (common carotid ≥0.7 mm) at baseline, which may increase the probability of detecting a treatment effect.
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We will adjust for additional baseline co-variates which may increase power.
As well, there are two distinct ID services at the hospital with higher baseline consultation rates (an immune-compromised and immune-competent service), which may increase accessibility to ID consultation.
These findings are consistent with our observation that LCR hearts have increased geometric dimensions and SV at baseline which may reflect a compensatory remodeling response to this increased β-MHC in the heart.
We sought for factors at baseline which may independently predict the CD4 T-cell drop and the increase in viral load following TI and found no impact of Tregs on the immunovirologic outcome at 12 months of TI.
This study had some selection biases at baseline, which may decrease generalizability.
The "baselines" which may not be exceeded will be set at the highest reported emissions over the five-year period from 2009-10 to 2013-14.
Baseline defects predicted site-specific BML progression, which may represent increased bone loading adjacent to defects.
Baseline cartilage defects predicted site-specific BML progression, which may represent increased bone loading adjacent to defects.
This guard band prevents the most recent data being included in the baseline estimates, which may be detrimental in the case of slowly increasing incidence being incorporated into the baseline.
Change in LIC was more pronounced in patients with higher baseline LIC which may reflect either higher dose of deferasirox used or a potentially increased molecular efficiency of the chelator in severely iron overloaded patients.
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