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We defined a relevant change as more than ± 0.5 standard deviations (baseline) which has been recommended by [ 31, 32], corresponding to 11 LSAS total score points.
The patients included in the present study, however, had persistent symptoms with low disability values at baseline, which has been reported to be associated with a poorer prognosis.
Interestingly, we found mean hs-CRP of ∼16 mg/L (range 11 25 mg/L) at baseline, which has been associated with increased risk (>3 mg/L) of future cardiovascular disease (Ridker et al., 2002).
We assumed that the score of both EQ-5D indexes and the EQ VAS stay constant if the change in LSAS total score stays within range of 0 ± 0.5 standard deviations (baseline) which has been recommended by [ 31, 32], corresponding to 11 LSAS total score points.
Associations were also similar in those with both higher and lower serum cholesterol levels at baseline, which has been previously associated with liver disease and subsequent liver cancer in this and other cohorts (Cicognani et al, 1997; Ahn et al, 2009; Kitahara et al, 2011).
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We compare our MMPP approach with a baseline model, which has been explained in Section 3.2, and show that our approach outperforms the baseline.
Glutamate levels were highest at the start of monitoring and gradually returned to near normal baseline values, which has been nicely documented in experimental SAH models [ 37].
We also observed that detection of a signal of a fixed size increases as the baseline counts decrease, which has been observed elsewhere[ 13].
Correspondingly, our observation of effect modification by diabetic status in the association between traffic pollution and parasympathetic tone may be due to a higher likelihood of diabetics to have decreased parasympathetic tone than non-diabetics [ 25] and/or to their greater baseline oxidative stress, which has been shown to mediate the autonomic effects of particles [ 26- 28].
Effect in terms of QALYs will be analysed using linear regression on type of intervention and – if necessary – on baseline utility score, which has been shown to be important for the unbiased assessment of mean QALY differences between treatment groups [ 31].
This explains the relatively low baseline for competent leadership, which has been estimated at around 30%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com