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Comparisons between the groups at baseline were made with t-tests in the case of continuous variables and Fisher exact tests in the case of dichotomous variables.
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Due to the small number of subjects, comparisons of periods 2 6 with baseline were made using estimates from a mixed-effects regression model.
Statistical comparisons between healthy controls and HT alone or T2DM HT baseline levels were made with one-way ANOVA followed by Bonferroni post hoc test.
Baseline data comparisons were made with Fisher's exact test (for proportions) or the Mann-Whitney test (for continuous variables).
Baseline group comparisons were made with the use of Wilcoxon rank-sum tests and Fisher's exact tests where appropriate.
Comparisons of visual measures (VQOL or VA) at baseline versus 1 year were made with paired t tests.
At baseline, diagnoses of PDs were made with the use of the Personality Disorder Examination, and Axis I-disorders were diagnosed by the MINI-International Neuropsychiatric Interview.
Baseline comparisons between groups were made with the Student t test, Mann-Whitney U test, χ2 test, or Fisher Exact test where appropriate.
Comparisons of baseline values and mean changes from baseline to year 1 between the groups were made with a two-tailed unpaired t test or the χ2 test when applicable.
Comparisons were made with normal baseline and with the 0 nM FVIIa dose level within each experimental condition.
Buffer and baseline subtraction from the obtained spectra were made with rescaling in the wave number range of 900 1800 cm−1.
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