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Throughout the study, lesions measured at baseline were evaluated using the same technique (CT or contrast-enhanced US).
Variables associated with kinesiophobia at baseline were evaluated using multivariate linear regression analyses.
Biomarker data were log2-transformed, and changes from baseline were evaluated using one-sample t tests.
Dose profiles for mean changes from baseline were evaluated using weighted MSM with a repeated measures model.
Within-group changes from open-label baseline were evaluated using paired t tests; categorical differences were assessed by Fisher exact test.
If an overall effect was identified (LPS × time interaction), the estimated individual differences from baseline were evaluated using the Tukey-Kramer adjustment for multiple comparisons.
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The association between physical activity and depressive symptoms at baseline was evaluated using multivariate linear and logistic regression models.
Physical disability at baseline was evaluated using the basic Activities of Daily Living [ 17] that investigates 6 domains providing a score ranging from 0 (total disability) to 6 (no disability).
Differences in baseline characteristics were evaluated using t-tests for continuous variables and χ tests for categorical variables.
The relationships between the magnitude of the change in blood glucose with glycated haemoglobin, Acute Physiology and Chronic Health Evaluation (APACHE) II score, and baseline glucose were evaluated using linear regression [ 13].
Percentage changes in all parameters (BMD measured by DXA, NTX, TRACP-5b, PICP, and RANKL) at 0, 6, 12, and 18 months in the Bis and Bis + statin groups relative to the baseline measurements were evaluated using the Wilcoxon signed ranks test, and differences in percentage changes at 0, 6, 12, and 18 months between the Bis and Bis + statin groups were evaluated using the Mann-Whitney U-test.
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