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Comorbidities at baseline were estimated using the Charlson Comorbidity Index (24).
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Habitual lycopene intake at baseline was estimated using summary values of lycopene content in tomato products based on five databases by Porrini M and Riso P [ 32].
The risk of developing CIN2+ lesions according to histology data by cytology and HPV test results at baseline was estimated using the Kaplan Meier method.
39 Level of physical activity at baseline was estimated using the question: 'With exception of school activity, how many days a week do you practice sports or exercise to the point where you breathe heavily and/or sweat?'.
The baseline is estimated using a complex algorithm based on histogram and STV analysis, aimed at finding the HR level of stable segments with normal variability, within the physiological limits of 110 150 bpm [ 14– 16].
Baseline levels were estimated using the Bangladesh Urban Health Survey 2006 [ 7], and it was assumed that the program would achieve a 50% improvement in these indicators with a design effect of 1.5 (to adjust for the clustered sample).
First, associations of baseline pain with baseline coping strategies were estimated using ordinary least squares regression models.
Population clearance, volume of distribution, and the baseline magnesium concentration were estimated using the NONMEM program.
The baseline incidence rates were estimated using the incidence in the 50-59 and 60-69 years old age groups in the period before screening, 1980-1989.
Our main analyses used modeled-based estimates of average PM2.5 and NOx concentrations at participants' residences during the year before the baseline exam, which were estimated using intensive MESA-specific measurements as well as more spatially limited data from the U.S. Environmental Protection Agency's Air Quality System (AQS; http://www.epa.gov/ttn/airs/airsaqs/).
Probabilities for changes in category from baseline to Week 12 were estimated using a logistic regression of the data set, excluding the few subjects with missing or best (5) baseline category or with missing outcome category (see Table 2 and Figure 4).
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