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Differences in cytokine expression against baseline were analyzed using the Wilcoxon's matched-pairs signed-rank test.

Intra-group changes from the baseline were analyzed using the signed rank test.

Changes from baseline were analyzed using ANCOVA, taking baseline values and age as covariates.

Between-group comparisons at baseline were analyzed using independent samples t-test for continuous variables and χ for categorical variables.

Changes from baseline were analyzed using ANCOVA with region and treatment as factors, and baseline as covariate (using LOCF imputation of missing data).

Changes from baseline were analyzed using ANCOVA, with treatment and geographic region as class effects and baseline value as a continuous covariate.

Change from baseline was analyzed using a linear mixed effects model including covariates of treatment, visit, treatment by visit interaction, stratification factors (region and migraine prophylaxis medication status), and baseline value.

The log of the mean ratio in PASI score over baseline was analyzed using a D R meta-analysis, yielding model parameters for mean % change in PASI score (Table 1 ).

Baseline characteristics were analyzed using Wilcoxon rank-sum test for continuous and Chi-Square test or Fisher's Exact test for categorical variables.

Categorical baseline characteristics were analyzed using Pearson's χ2 test.

Differences in baseline characteristics were analyzed using the Students' t-test.