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Significantly greater reductions in evening pain from baseline were also seen for the MR prednisone group (p<0.05) (table 2).
Statistically significant reductions from baseline were also seen in triglycerides for LY2140023 80 mg treatment group (p = .028).028
Statistically significant improvements from baseline were also seen in stool frequency, body weight and BMI (Table 4).
A significant reduction in the mean change in T2 lesion volume and T1 hypointense lesion volume from baseline was also seen at 36 months [20,21].
Furthermore, increasing mortality rates with increasing YKL-40 levels at baseline are also seen over a 5 year period in the general population above 50 years of age without known diabetes or CVD in which YKL-40 were also found to be an independent predictor of overall as well as of cardiovascular mortality (Table 1) [ 32]. 1 SD increase in ln variable.
Trends in LL reductions from baseline to posttreatment, respectively, were also seen for CD68 (3.58 and 3.0) and CD55 (2.93 and 2.28) with a small reduction in LL depth from 1.45 to 0.96 (fig 1A), although these changes were highly variable.
Subgroup analyses based on baseline HbA1c (<8%, ≥8 to <9% and ≥9%) showed that HbA1c reductions with canagliflozin were greater in the subgroup with higher baseline HbA1c; however, sizeable reductions were also seen in the subgroup with the lowest baseline HbA1c (figure S1).
The lack of influence of BMI, age, diabetes duration and baseline HbAlc on disease progression was also seen in a non-interventional observation study of LADA that followed 13 Ab-positive patients by stimulated C-peptide for 2 years (16).
This was also seen in baseline analyses in the VADT, where increasing baseline severity of retinopathy was significantly correlated with lower eGFR and higher levels of albuminuria (21).
